Burn
injury is the main cause of death and insufficiency and also due to the high
cost of health care, healing of burn wounds remains a challenge for modern
medicine (Saeidinia et al. 2017). The skin provides a protecting
barrier against infection (Stevens et al. 2014). One of the microorganisms
noticeably isolated from infectious burn sites is Pseudomonas aeruginosa. It
may lead to septicaemia and death in burn patients (Turner et al. 2014). Though there are many topical
anti-bacterial agents, disinfectants and protection against infection, these
agents may actuate allergic reaction and skin irritation that could increase
the recovery time (Thomas et al. 2009). Silver sulfadiazine (SSD) with
strong anti-microbial effect is still used topically for burn injury treatment,
but delayed wound healing is an important adverse effect (Jewo et al. 2009; Tehrani
et al. 2016). On the other
hand, renal toxicity, leucopenia, resistance of this topical agent, and
long-term usage on extensive wound are not recommended (Atiyeh et al. 2007). Accordingly, finding better
alternative burn dressing and more effective drugs with shorter time period is
important. Many natural products have been found to possess the therapeutic
potential effects and promote wound healing rapidly which more affordable and
less toxic compared to synthetic drugs (Ashkani-Esfahani et al. 2012; Nakajima
et al. 2013; Tanideh et al. 2015).

Eucalyptus
camaldulensis (EC), Myrtaceae family, is a native Australian and middle-eastern
plant (Sadlon and Lamson 2010). The bioactive ingredient,
eucalyptol (1,8- cineole) has been found to have various pharmacological
effects, significant anti-microbial, anti-inflammatory and immune stimulatory
properties (Huang et al. 2015). Eucalyptol has been used to treat
respiratory diseases such as sore throat, bronchitis, sinusitis, and other
infections on the urinary tract. Moreover, by increasing blood circulation this
compound causes hyperemia after topical application (Pereira et al. 2014). Eucalyptus oil is generally
non-irritating, non-sensitizing and non-phototonic on the skin (Gilles et al. 2010).

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On
the other hand, licorice is a traditional herb belonging to the Papilionaceae
family which detoxifies and protects the liver and also has an intense
anti-inflammatory activity in arthritis and mouth ulcer which grows in
different parts of the world (Jung et al. 2015). Numerous substances have been
isolated from licorice; Glycrrhizic acid is its main biologically active
component and ?-glychrritinic acid is the major metabolite of glycrrhizin that
has shown anti-inflammatory properties (Karao?ul et al. 2016). The salubrious effects of
licorice that are reported include antioxidant, antimicrobial,
anti-inflammatory, anti-arrhythmic, and expectorant activity (Yang et al. 2017). This herb is medically used for
treatment of the upper respiratory disorders including cough, sore throat, and
bronchitis (Tanaka et al. 2008). The aims of the current study
were to investigate the healing efficacy of eucalyptus and the mixture of
eucalyptus with licorice on infected 3rd degree burn wounds in rats.

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