Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosisRS Koeth et al (2013)The microbiota (microorganisms) of the human gut has diverse health effects depending on its composition in the human gut. There are almost 10 times as many microbes in a human body then there are human cells, with this many microbes that live in the human body there are sure to be benefits from having them there. The microbes in the gut have a diverse role in what they do from protecting the body against foreign pathogen to overall gut development into maturity and correctfunctions. The microbes that make up the microbiota in a body are shared throughout the population, this is done by living in the same places through different mediums including touch breathing and feeding (breastfeeding a baby). The transmission of these sorts of bacteria is harmless and in many cases helpful for normal growth of the human body to protect it from its habitat, decreasing risks of Asthma and celiac diseases in babies. This article looks at the other side of having the microbiota in the human gut and how it can also lead to unwanted conditions and the negative side effects of having the bacteria within us. It looks further into intestinal microbiota and its metabolism of choline, L-carnitine and its effects on the body.L-carnitine and choline are similar in their structure and thus undergoes similar catabolism pathways producing TMA (trimethylamine) which can then be turned to TMAO (trimethylamine-N-oxide) which is done by the gut microbiota as the human bodydoesn’t have the correct components to catabolise this. TMAO and TMA are known to be of a species that promote fatty deposits throughout the bod, mainly in the arteries and thus linked to CVD (Cardiovascular Diseases). Upon further looking into this the researchers also found a link between eating read meat (which high levels of L-carnitine) and accelerated atherosclerosis in mice. Which suggests that the microbiota in the body is reliant on the diet that we consume, in the way it develops and carry out it functions as a Omnivorous humans produced far more TMAO then Vegans and Vegetarians, after consuming L-carnitine. The research has lots of implications on what the role of the microbiota is and how it functions in the human body. Not only does it show that our diets play a big role in our overall health and how the human system breaks down molecules, it also shows us that parts of out diet that human body can’t process the microbiota that we have within us can.

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